Rotation 7: Family Medicine

History & Physicals:

Journal Article Summary

Expert groups have advocated for the screening of pancreatic cancer in high-risk individuals, but prior research establishing if there is a beneficial outcome to screening measures had not previously been performed. Therefore, the multicenter Cancer of Pancreas Screening (CAPS) study aimed to establish the benefits of screening in terms of earlier detection, impact on management, and overall survival outcomes. Over 1700 participants were enrolled and of those individuals, 48.5% had a pathogenic variant in a PDAC-susceptibility gene. The screenings resulted in 1/160 individuals being diagnosed with pancreatic cancer. Of those diagnosed, 57.9% still had stage I and only 5.2% were diagnosed with stage IV disease. For perspective, 85.7% of typical diagnose are stage IV. The-fiver year survival rate for screening individuals was 73.3% which is significantly improved compared with standard combined survival rates which is 5-10%. Patients enrolled in the study lived an average of 9.8 years after diagnosis whereas individuals typically only live 24-39 months after initial diagnosis. In conclusion, yearly screenings with MRI for individuals identified as high-risk based on genetic predisposition should be implemented based on the strong evidence presented in this randomized controlled trial.

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